Potent Anti-Tumor Drug Formation Using Enzymes Extracted From Marine Microorganism

Immense range of biodiversity of microorganism provides us with endless possibilities to produce secondary metabolites to deal with the rapidly changing environment. Due to broad biochemical diversity of microorganism the enzymes produced by them are relatively much more stable and active than the corresponding enzymes isolated from plants and animals (Kin, 2006). Secondly plants and animals are have a long life cycle; therefore, microorganisms represent a better alternative source of enzymes because microorganisms can be cultured in large quantities in the laboratories in short amount of time. Most of the pharmaceutical drugs are derived from terrestrial plants due to their easy accessibility and only a small fraction of drugs are derived using microbial natural products. Recently marine microorganisms have been attracting more attention as a resource for enzymes with novel properties because as compared to terrestrial environment the complexity of the marine environment involving high salinity, high pressure and wide temperature range, fluctuations in nutrient level and special lighting conditions have given rise to microorganism with unique genetic makeup (Jha & Zi-rong, 2004). Now due to this extensive genetic diversity there is significant difference between the enzymes produced by the marine microorganism and their corresponding enzymes produced by terrestrial microorganism. Marine microorganisms, because of their extensive genetic and biochemical diversity are of substantial interest as a new hopeful source of enzymes with unsuspected application potentials (Ghosh et al, 2005).